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前报报道在“催醒安”的对位异构体的苯环上引入烷基,可以增强对胆碱酯酶的抑制作用。为了探索在邻位异构体(Ⅰ)的苯环上引入烷基对生理活性的影响,合成了二甲氨基甲酸-[2-(2-二甲氨基)乙氧基-4(或5)-特丁基]苯酯(Ⅱ)。
Former report reported that the introduction of alkyl on the benzene ring of the para-isomer of “Awakening An” could enhance the inhibitory effect on cholinesterase. In order to explore the effect of introduction of alkyl on the phenyl ring of the ortho-isomer (Ⅰ), the activity of dimethylcarbamate - [2- (2-dimethylamino) ethoxy-4 -tetrabutyl] phenyl ester (II).