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Toll样受体(Toll-like receptor,TLRs)是一类受体蛋白,其家族成员通过识别各自特异的病原体相关分子模式(PAMP)来启动天然免疫和获得性免疫应答,从而抵抗病原微生物对机体的入侵。对于TLRs在抗感染免疫中所起的作用及其可能的机制已经进行了大量的研究。本文将对TLRs与抗病毒免疫应答的研究进行综述,这将有助于更好地理解Toll样受体介导的抗病毒免疫机制,为预防、干预、治疗病毒感染性疾病新策略新方案的提出提供指导。
Toll-like receptors (Toll-like receptors, TLRs) are a family of receptor proteins whose family members initiate innate and adaptive immune responses by recognizing their specific pathogen-associated molecular patterns (PAMPs), thereby counteracting the effects of pathogenic microorganisms on the body The invasion. Much research has been done on the role of TLRs in anti-infective immunity and its possible mechanism. This review summarizes the studies of TLRs and antiviral immune responses, which will help to better understand the Toll-like receptor-mediated antiviral immune mechanism and provide a new strategy for the prevention, intervention and treatment of viral infectious diseases Proposed to provide guidance.