吸烟与氡是导致肺癌的两个主要因素,氧化损伤和基因突变是两个主要的机制。氧化损伤涉及多种自由基,而发生突变的基因主要包括p53基因、K-ras基因、p16基因、O6-MGMT基因和FHIT基因。通过对吸烟和氡致肺癌的氧化损伤与基因突变方面的对比研究,可为肺癌发生的机制提供新的线索。 Smoking and radon are the two major contributors to lung cancer, and oxidative damage and genetic mutations are two major mechanisms. Oxidative damage involves many kinds of free radicals, while the mutated genes mainly include p53 gene, K-ras gene, p16 gene, O6-MGMT gene and FHIT gene. By comparing the oxidative damage and gene mutation caused by smoking and radon in lung cancer, we can provide new clues for the mechanism of lung cancer.