外周Ｂ细胞异常增生是系统性红斑狼疮（ＳＬＥ）突出的免疫学异常表现之一。近年来愈来愈多的研究表明淋巴细胞凋亡异常与包括ＳＬＥ在内的多种自身免疫病的发生有关。本文采用ＴＵＮＥＬ法结合流式细胞分析技术，对ＳＬＥ模型－ＢＸＳＢ小鼠脾脏中Ｂ细胞凋亡的情况进行了检测，发现该小鼠脾脏Ｂ细胞凋亡发生率明显高于正常对照小鼠。提示Ｂ细胞凋亡异常可能与ＳＬＥ小鼠Ｂ细胞的异常增生有关。 Peripheral B cell dysplasia is one of the prominent immunological abnormalities in systemic lupus erythematosus (SLE). In recent years, more and more studies have shown that abnormal lymphocyte apoptosis and SLE, including a variety of autoimmune diseases. In this study, TUNEL method combined with flow cytometry analysis of SLE model-BXSB mouse spleen B cell apoptosis was detected and found that the mouse spleen B cell apoptosis was significantly higher than the normal control mice. It is suggested that the abnormal apoptosis of B cells may be related to the abnormal proliferation of B cells in SLE mice.