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目的:探究首次发病的抑郁症患者视觉通道中返回抑制效应的情况。方法:选用线索-靶子模式的返回抑制实验范式,对29例抑郁症患者和29例健康对照组进行视觉通道测试。结果:抑郁症患者及正常对照组视觉通道中均存在返回抑制效应,抑郁症患者视觉通道的返回抑制效应约在时间间隔为700ms出现,而正常对照组约在时间间隔为300ms出现。结论:抑郁症患者与正常人的视觉通道返回抑制效应神经机制存在不同,抑郁症患者返回抑制效应异常可能与额叶、前扣带回、丘脑等部位的功能异常有关,从而引起注意功能的损害。
OBJECTIVE: To investigate the inhibitory effect of return on the visual pathway in the first episode of depression. Methods: The clues-target model was used to test the return inhibition. Visual pathways were performed in 29 patients with depression and 29 healthy controls. Results: The regression of visual acuity was observed in patients with depression and in normal controls. The inhibitory effect of visual channel in depression was about 700 ms, while that in normal control was about 300 ms. Conclusions: There are differences in the neural mechanism of the depression of visual pathway between depression and normal subjects. The abnormality of return inhibition in patients with depression may be related to dysfunction of the frontal lobe, anterior cingulate gyrus and thalamus, which may lead to impairment of attentional function .