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A series of substituted 2,3-diaryl-2-azabicyclo[2.2.2]octan-5-ones have been prepared by an efficient three-component aza-Diels-Alder cycloaddition reaction in water catalyzed by layeredα-zirconium hydrogen phosphate(α-ZrP) and sodium calix[4]arene sulfonates bearing pendant short aliphatic chains.The 18 synthesized compounds were assayed for acetylcholinesterase inhibition using mouse acetylcholinesterase.
A series of substituted 2,3-diaryl-2-azabicyclo [2.2.2] octan-5-ones have been prepared by an efficient three-component aza-Diels-Alder cycloaddition reaction in water catalyzed by layered α-zirconium hydrogen phosphate -ZrP) and sodium calix [4] arene sulfonates bearing pendant short aliphatic chains. The 18 synthetic compounds were assayed for acetylcholinesterase inhibition using mouse acetylcholinesterase.