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目的 :探讨CIC和IgE与妊高征血管内皮损伤的关系。方法 :CIC采用PEG NaF沉淀比浊法 ,IgE采用ELISA双抗体夹心法进行测定。结果 :妊高征产前组的IgE与正常妊娠组相比明显升高 ,与自身对照的产后组相比无显著性差异 ,妊高征产后组的IgE与对照组相比明显增高。妊高征产前组的CIC与对照组、自身对照的产后组相比明显升高 ,妊高征产后组的CIC与对照组相比明显升高。结论 :IgE在妊高征胎盘的母体面和母体的其它重要脏器引起I型变态反应 ,导致VEC的损伤 ;CIC在妊高征的胎盘等处引起明显的血管病变 ,类似于Ⅲ型变态反应 ,从而导致VEC的损伤。
Objective: To investigate the relationship between CIC and IgE and vascular endothelial injury induced by pregnancy induced hypertension. Methods: CIC was determined by PEG NaF precipitation turbidimetry and IgE by ELISA double antibody sandwich method. Results: The IgE of pre-PIH group was significantly higher than that of normal pregnancy group, but no significant difference compared with that of self-control postpartum group. IgE of pre-PIH group was significantly higher than that of control group. Compared with control group and self-control postpartum group, CIC in prenatal PIH group was significantly higher than that in control group. CIC in post-PIH group was significantly higher than that in control group. CONCLUSIONS: IgE causes type I anaphylaxis in the maternal surface of the placenta and other important organs of the mother during pregnancy-induced hypertension, leading to VEC injury. CIC causes significant vascular lesions in the placenta of pregnancy-induced hypertension similar to type III allergy , Resulting in VEC damage.