1概述慢性淋巴细胞白血病(CLL)是B细胞慢性淋巴增殖性疾病(B-CLPD)最常见的一种类型,为成熟B细胞肿瘤,以单克隆、成熟的CD5+B淋巴细胞在外周血、骨髓和肝脾进行性积聚为特征。2008年CLL国际工作组(IWCLL)规定的CLL诊断标准:外周血B淋巴细胞≥5×109/L,持续≥3个月;但如伴有骨髓浸润引起的血细胞减少及典型的形态学、免疫表型特征,不管外周血B淋巴细胞数或淋巴结是否受累,也应诊断为CLL。小淋巴细胞淋巴瘤(SLL)与CLL是同一种疾病,为CLL的非白血病表现,二者统称为CLL/SLL。SLL患者表现为淋巴结肿大、无CLL/SLL骨髓浸润所致的血细胞减少及外周血B细胞<5×109/L。 1 Overview Chronic lymphocytic leukemia (CLL) is the most common type of B-cell chronic lymphoproliferative disease (B-CLPD) and is a mature B-cell tumor with monoclonal, mature CD5 + B lymphocytes in peripheral blood, Bone marrow and liver and spleen accumulation was characterized. 2008 CLL International Working Group (IWCLL) provides diagnostic criteria for CLL: peripheral blood B lymphocytes ≥ 5 × 109 / L, sustained ≥ 3 months; but as associated with bone marrow infiltration caused by cytopenia and typical morphological, immune Phenotypic characteristics, regardless of peripheral blood B lymphocytes or lymph nodes are involved, should also be diagnosed as CLL. Small lymphocytic lymphoma (SLL) is the same disease as CLL and is a non-leukemotic manifestation of CLL, both collectively referred to as CLL / SLL. SLL patients showed swollen lymph nodes, no CLL / SLL bone marrow infiltration caused by cytopenia and peripheral blood B cells <5 × 109 / L.