治疗双相情感障碍常使用某种情感稳定剂，当抑郁发作时，临床常追加另一种情感稳定剂，或抗抑郁剂。本文就此作一双盲对比研究。２７例门诊病人，符合ＤＳＭ－Ⅳ诊断标准，其时发生抑郁发作，排除精神病性和快速循环型双相障碍。病人半年内无酒精或药物滥用，无急性躯体疾病。 Treatment of bipolar disorder often use some kind of emotional stabilizer, when depressive episodes, clinical often add another emotional stabilizer, or antidepressant. This article made a double-blind comparative study. 27 outpatients, in line with DSM-Ⅳ diagnostic criteria, the occurrence of depressive episodes, excluding psychosis and rapid cycling bipolar disorder. Within six months, the patient had no alcohol or substance abuse and no acute physical illness.