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本文分析了居住在加拿大的101例中国人的apoE表型和其等位基因顷率以及性别、身高、体重、年龄、膳食和血浆各项脂质指标(TG、Chol、HDL-C,LDL-B,apoB,apoE)。 101例中国人中,E 3/3占65.3％,E3/4占10.9％,E2/3占22.8％,E2/4占1.0％。未发现E2/2和E 4/4二个纯合子。其中apoE 3/3离于西方人群。ε 3等位基因为0.822,也明显高于西方人群:结果分析表明,在加拿大居住时间的长短明显地影响TG水平。居住时间每噌加一年,TG约增加7.23mg/dl;其它血脂水平,如LDL—apoB、VLDL—chol,等也与居住时间的长短有密切关系。HDL-C阳HDL_2-C与性别有密切关系。还分析了等位基因ε2、ε3和ε4对血脂水平的影响,并与西方人群等位基因的相对频率进行了比较。
In this study, we analyzed the apoE phenotype and its allele rate as well as the sex, height, weight, age, dietary and plasma lipid profiles (TG, Chol, HDL-C and LDL- B, apoB, apoE). Among 101 Chinese, E 3/3 accounted for 65.3%, E3 / 4 accounted for 10.9%, E2 / 3 accounted for 22.8% and E2 / 4 accounted for 1.0%. No two homozygotes of E2 / 2 and E 4/4 were found. ApoE 3/3 from Western populations. The ε 3 allele was 0.822, which was also significantly higher than in Western populations: Results Analysis showed that length of residence in Canada significantly affected TG levels. Residence time per bass plus one year, TG increased by about 7.23mg / dl; other blood lipid levels, such as LDL-apoB, VLDL-chol, etc. are also closely related with the length of living. HDL-C Yang HDL_2-C and gender are closely related. The effect of the alleles ε2, ε3 and ε4 on blood lipid levels was also analyzed and compared with the relative frequency of alleles in Western populations.