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目的:探讨INF-γ和IL-10在慢性乙型重型肝炎中的作用。方法:搜集不同患者血样,提取血清,使用ELISA方法检测不同患者不同时期的血清INF-γ和IL-10水平,并进行相关统计。结果:本研究发现,和其它肝炎对照组及健康对照组相比,慢性乙型重型肝炎患者的血清INF-γ水平显著升高,IL-10水平显著降低。尽管在不同预后的患者中,INF-γ水平差异并不明显,但是随着治疗生效,INF-γ水平会出现明显的下降。结论:慢性乙型重型肝炎和其它慢性肝炎相比,INF-γ和IL-10表达存在着差异,而且INF-γ可能是一种比较有效的监控慢性重型肝炎病程以及疗效的指标。
Objective: To investigate the role of INF-γ and IL-10 in chronic severe hepatitis B. Methods: Blood samples from different patients were collected and serum was extracted. Serum levels of INF-γ and IL-10 in different patients at different periods were detected by ELISA, and statistics were obtained. Results: This study found that, compared with other hepatitis control group and healthy control group, serum INF-γlevel of patients with chronic severe hepatitis B was significantly increased, IL-10 levels were significantly reduced. Although there is no significant difference in the level of INF-γ in patients with different prognoses, the level of INF-γ significantly decreases as the treatment takes effect. CONCLUSIONS: There are differences in the expression of INF-γ and IL-10 between chronic hepatitis B and other chronic hepatitis, and INF-γ may be an effective indicator to monitor the course of chronic severe hepatitis and its curative effect.