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目的:研究孕妇血浆同型半胱氨酸水平与早产的关系。方法:采用病例对照研究,用高效液相色谱荧光检测法(HPLC-FD)检测60例孕28~34周早产孕妇(病例组)和30例非早产于孕31~34周采血的正常妊娠孕妇(对照组)的血浆同型半胱氨酸水平。用Logistic回归分析等统计方法分析孕妇血浆同型半胱氨酸水平与早产的相关性。结果:病例组血浆同型半胱氨酸水平(7.56±2.97μmol/L)显著高于对照组(5.96±2.54μmol/L),P=0.013;排除混杂因素的影响,早产孕妇血浆同型半胱氨酸水平升高没有明显增加早产发生的风险,其血浆同型半胱氨酸水平升高会增加分娩早产小于胎龄儿(SGA)的机会,尤其是血浆同型半胱氨酸水平≥11.0μmol/L时分娩SGA的机会明显增加(χ2=8.579,P=0.003);未见早产儿其他并发症增加。结论:孕妇血浆同型半胱氨酸水平升高不会明显增加早产发生的风险,而会显著增加分娩小于胎龄儿的机会。
Objective: To study the relationship between plasma homocysteine and preterm labor in pregnant women. Methods: A case-control study was conducted in 60 preterm pregnant women with gestational age between 28 and 34 weeks (case group) and 30 pregnant women with nonpregnant fetuses who were prematurely born at 31 to 34 weeks of pregnancy by high performance liquid chromatography with fluorescence detection (HPLC-FD) (Control group) plasma homocysteine levels. Logistic regression analysis and other statistical methods to analyze the correlation between plasma homocysteine levels and preterm labor in pregnant women. Results: The level of plasma homocysteine (7.56 ± 2.97μmol / L) in the case group was significantly higher than that in the control group (5.96 ± 2.54μmol / L), P = 0.013. The influence of confounding factors, the plasma homocysteine Elevated acid levels did not significantly increase the risk of preterm labor, and elevated plasma homocysteine increased the chances of delivering preterm labor less than gestational age (SGA), especially plasma homocysteine levels ≥11.0 μmol / L There was a significant increase in the chance of delivery of SGA (χ2 = 8.579, P = 0.003); no additional complications were seen in preterm infants. CONCLUSIONS: Elevated plasma homocysteine levels in pregnant women do not significantly increase the risk of preterm birth, but significantly increase the chances of giving birth to less than gestational age children.