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目的研究人参三醇组皂苷(Panaxtrol Saponin,PTS)对大鼠坐骨神经急性损伤病理学改变的影响。方法建立大鼠坐骨神经挤压损伤模型,随机分为PTS组,模型对照组及空白对照组,每组各10只大鼠;各组均经腹腔注射给药,PTS组损伤后注射PTS;模型对照组损伤后注射同剂量生理盐水;空白对照组,不损伤坐骨神经,注射同剂量生理盐水。坐骨神经损伤术后30 d,观察大鼠健侧、损伤侧腓肠肌湿重及恢复率,大鼠坐骨神经急性损伤及腓肠肌损伤病理学改变。结果 PTS处理组的损伤侧腓肠肌湿重及腓肠肌恢复率(1.28±0.36、83.82±9.21)与模型对照组(0.90±0.44、55.43±22.02)比较差异有统计学意义(P<0.05);PTS处理组坐骨神经与模型对照组比较,神经纤维排列更整齐,轴索更清晰,雪旺细胞基本保持正常。PTS处理组腓肠肌与模型对照组比较,肌细胞直径更均匀,胞核更清晰,数量增多,但少于模型对照组,肌纤维萎缩程度较轻。结论人参三醇组皂苷对大鼠坐骨神经急性病理损伤有一定的修复作用。
Objective To investigate the effect of Panaxtrol Saponin (PTS) on pathological changes of acute sciatic nerve injury in rats. Methods The model of sciatic nerve crush injury in rats was established and randomly divided into PTS group, model control group and blank control group with 10 rats in each group. Each group was given intraperitoneal injection and PTS group was injected with PTS. The model control The rats were injected with the same dose of saline after injury. The blank control group did not injure the sciatic nerve and injected the same dose of saline. After 30 days of sciatic nerve injury, the wet weight and recovery of gastrocnemius muscle in injured and injured sides were observed. The injury of sciatic nerve and the pathological changes of gastrocnemius injury were observed. Results The wet gastrocnemius and gastrocnemius muscle recovery rate of injured side gastrocnemius and the gastrocnemius muscle in PTS group were significantly lower than those in model control group (0.90 ± 0.44 and 55.43 ± 22.02 vs 1.28 ± 0.36 and 83.82 ± 9.21, P <0.05) Group sciatic nerve compared with the model control group, nerve fibers arranged more neat axonal clearer, Schwann cells remained normal. Gastrocnemius muscle in PTS treatment group was more uniform in diameter and more in number than in model control group, but less in muscle group than in model control group. Conclusion Ginseng triol saponin has a certain repair effect on acute pathological injury of sciatic nerve in rats.