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目的探讨外周血纤维蛋白原(FIB)、IL-6、CA125水平在卵巢癌诊断中的价值和临床意义。方法选取2012年5月-2013年10月该院收治的卵巢癌患者65例为卵巢癌组,另选取该院同期收治的卵巢良性肿瘤患者35例为卵巢良性肿瘤组、健康体检者30例为对照组。取3组研究对象的血清及血浆,采用胶乳凝集法测定血浆中的FIB,采用电化学发光法测定血清CA125含量,采用ELISA法测定IL-6水平。结果卵巢癌组患者FIB、IL-6和CA125水平明显高于卵巢良性肿瘤组和对照组,差异有统计学意义(P<0.05);卵巢良性肿瘤组FIB、IL-6和CA125水平与对照组比较,差异无统计学意义(P>0.05)。卵巢癌组FIB、IL-6和CA125水平随着临床分期的升高而升高。相关性分析表明,FIB和CA125与IL-6水平呈正相关(r=0.34,r=0.54)。结论 FIB、IL-6和CA125联合检测对于卵巢癌的早期诊断、分期及判断预后具有重要的临床价值。
Objective To investigate the value and clinical significance of peripheral fibrinogen (FIB), IL-6 and CA125 levels in the diagnosis of ovarian cancer. Methods 65 patients with ovarian cancer admitted to our hospital from May 2012 to October 2013 were selected as ovarian cancer patients. Another 35 patients with benign ovarian tumors were selected as benign ovarian tumor patients at the same period, and 30 healthy subjects were Control group. Serum and plasma were taken from three groups. The FIB in plasma was determined by latex agglutination. The level of serum CA125 was determined by electrochemiluminescence. The level of IL-6 was determined by ELISA. Results The levels of FIB, IL-6 and CA125 in patients with ovarian cancer were significantly higher than those in benign ovarian tumors and controls (P <0.05). The levels of FIB, IL-6 and CA125 in patients with ovarian cancer were significantly lower than those in controls The difference was not statistically significant (P> 0.05). The levels of FIB, IL-6 and CA125 in ovarian cancer group increased with the increase of clinical stage. Correlation analysis showed that there was a positive correlation between FIB and CA125 and IL-6 (r = 0.34, r = 0.54). Conclusion The combined detection of FIB, IL-6 and CA125 has important clinical value for the early diagnosis, staging and prognosis of ovarian cancer.