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目的 探讨恶性胃肠道外间质瘤(EGIST)的临床表现、诊断、鉴别诊断和治疗。方法 回顾性分析3例恶性EGIST患者的临床病理资料。结果 3例恶性EGIST患者的临床表现均为腹、盆腔肿物,或伴腹水及肿瘤标记物轻度升高。术前均诊断为卵巢癌行开腹手术,术后经病理检查结合免疫组化染色CD117及CD34均呈阳性表达而确诊。手术为其首选治疗方法,术后辅以化疗可以改善其预后。结论 恶性EGIST与卵巢癌的临床表现有其相似性,需通过免疫组化染色CD117及CD34检测确诊。
Objective To investigate the clinical manifestation, diagnosis, differential diagnosis and treatment of malignant extraintestinal stromal tumors (EGIST). Methods The clinical data of 3 patients with malignant EGIST were retrospectively analyzed. Results The clinical manifestations of 3 malignant EGIST patients were mild abdominal, pelvic or ascites and tumor markers. Preoperative diagnosis of ovarian cancer were performed laparotomy, postoperative pathological examination combined with immunohistochemical staining of CD117 and CD34 were positive for diagnosis. Surgery for the treatment of choice, postoperative adjuvant chemotherapy can improve its prognosis. Conclusions The clinical manifestation of malignant EGIST and ovarian cancer have similarities and need to be confirmed by immunohistochemical staining of CD117 and CD34.