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目的分析非小细胞肺癌(NSCLC)患者外周血CD4+CD25+FoxP3+调节T细胞(Treg)占CD4+T细胞的比例变化,探讨其临床意义。方法采用流式细胞仪检测32例非小细胞肺癌患者和15例正常健康者(对照组)外周血中CD4+CD25+FoxP3+Treg占CD4+T细胞的比例。结果健康对照组外周血CD4+CD25+FoxP3+Treg占CD4+T细胞比例为(0.54±0.51)%;NSCLC患者外周血CD4+CD25+FoxP3+Treg占CD4+T细胞比例为(1.40±0.98)%。两组比较差异有统计学意义(P<0.01)。结论NSCLC患者外周血CD4+CD25+FoxP3+Treg占CD4+T细胞的比例明显升高,提示与肺癌免疫逃逸有关。
Objective To analyze the changes of CD4 + CD25 + FoxP3 + regulatory T cells (Tregs) in CD4 + T cells in peripheral blood of patients with non-small cell lung cancer (NSCLC) and to investigate their clinical significance. Methods Flow cytometry was used to detect the percentage of CD4 + CD25 + FoxP3 + Tregs in CD4 + T cells in 32 non-small cell lung cancer patients and 15 healthy controls (control group). Results The percentage of CD4 + CD25 + FoxP3 + Treg in CD4 + T cells in peripheral blood was (0.54 ± 0.51)% in healthy controls. The percentage of CD4 + CD25 + FoxP3 + Tregs in peripheral blood was (1.40 ± 0.98) %. The difference between the two groups was statistically significant (P <0.01). Conclusion The proportion of CD4 + CD25 + FoxP3 + Treg in CD4 + T cells in peripheral blood of patients with NSCLC is significantly increased, suggesting that it is related to immune escape of lung cancer.