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观察滋养细胞肿瘤患者及治愈后生育子女的外周血染色体脆性部位及畸变率。结果表明滋养细胞肿瘤患者的染色畸变率和脆性部位表达频率均明显高于对照组。尤其是脆性部1p32、2q31、3p14、7q32、14q24及16q22表达频率明显增加。化疗治愈后生育子女的染色体畸变率及脆性部位表达频率均与对照组无区别。
To observe the chromosomal fragile sites and the aberration rate in peripheral blood of patients with gestational trophoblastic tumor and cured children. The results showed that patients with gestational trophoblastic staining rate of distortion and the frequency of brittle parts were significantly higher than the control group. In particular, the expression frequencies of the brittle fractions 1p32, 2q31, 3p14, 7q32, 14q24 and 16q22 were significantly increased. The frequency of chromosomal aberrations and the frequency of the expression of the fragile parts of fertile children after chemotherapy were not different from the control group.