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喉癌是头颈部常见的恶性肿瘤,其发病率约占全身恶性肿瘤的5%[1],占耳鼻咽喉癌的11%～22%[2]。由于环境致癌因素的增加,喉癌的发病率呈不断增长趋势。虽然肿瘤诊断与治疗的手段日新月异,但全球的喉癌总体生存率并未得到明显改善,尤其是晚期病人[3]。如果能够早期诊断,无论采取手术、放疗都能使病人获得较好预后,还能保留喉的发音功能。Srinivus等[4]研究发现,肿瘤在早期即可伴随肿瘤标志物的改变,检测其含量变化有助于肿瘤的早期发现。因此,寻找理想的肿瘤标记物对早期诊断喉癌具有重要的临床意义,也是喉癌研究领域的热点。由于蛋白质组研究具有在整体水平上发掘和寻求潜在肿瘤标志物的能力,使其一经提出便受到肿瘤研究者的重视。
Laryngeal cancer is a common head and neck cancer, the incidence of about 5% of systemic malignancies [1], accounting for otolaryngopharyngeal carcinoma of the 11% to 22% [2]. Due to the increase of environmental carcinogens, the incidence of laryngeal cancer is increasing. Although the means of diagnosis and treatment of tumors are changing rapidly, the overall global survival rate of laryngeal cancer has not been significantly improved, especially in advanced patients [3]. If you can diagnose early, regardless of surgery, radiotherapy can make the patient a better prognosis, but also to retain the pronunciation of the throat function. Srinivus et al [4] found that the tumor can be accompanied by early changes in tumor markers to detect changes in its content contribute to the early detection of tumors. Therefore, looking for the ideal tumor markers for the early diagnosis of laryngeal cancer has important clinical significance, but also laryngocarcinoma research hot spots. Because proteomics research has the ability to explore and seek potential tumor markers as a whole, it has been put on the attention of tumor researchers once proposed.