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目的探讨无创正压通气(NIPPV)治疗慢性阻塞性肺疾病(COPD)急性加重期合并Ⅱ型呼吸衰竭的临床疗效。方法86例COPD急性加重期合并Ⅱ型呼吸衰竭的患者随机分为常规治疗组和NIPPV组各43例。NIPPV组在常规治疗的基础上给予NIPPV治疗。监测两组治疗前,治疗后6h、24h的血气参数和呼吸、心率变化。结果NIPPV组治疗后6h,PaO2即有显著上升,和治疗前比较,P<0.05;治疗后24h,PaCO2下降,pH值上升,呼吸频率降低,和治疗前比较,P<0.05。而常规治疗组治疗前后各指标无明显变化,P>0.05。结论NIPPV治疗COPD急性加重期合并Ⅱ型呼吸衰竭疗效肯定,值得临床推广。
Objective To investigate the clinical efficacy of noninvasive positive pressure ventilation (NIPPV) in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD) complicated with type Ⅱ respiratory failure. Methods A total of 86 patients with acute exacerbation of COPD and type Ⅱ respiratory failure were randomly divided into routine treatment group and NIPPV group (n = 43). The NIPPV group was treated with NIPPV on a routine basis. Blood gas parameters, respiration and heart rate were monitored before treatment, 6h and 24h after treatment. Results PaO2 was significantly increased 6 hours after treatment in NIPPV group, P <0.05 compared with that before treatment; PaCO2 decreased, pH value increased and respiratory rate decreased 24h after treatment, P <0.05. The conventional treatment group before and after treatment no significant change in each indicator, P> 0.05. Conclusion NIPPV treatment of acute exacerbation of COPD with type Ⅱ respiratory failure efficacy is worthy of clinical promotion.