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无细胞毒性浓度的粉防己碱（０．５ｍｇ·Ｌ－１），明显地增强三尖杉酯碱对人早幼粒白血病ＨＬ６０耐药细胞的生长抑制作用，降低集落形成率，但对敏感ＨＬ６０细胞没有增强作用。ＤＰＨ荧光标记法测定表明，粉防己碱对细胞膜流动性没有影响；提取经药物作用后的细胞ＤＮＡ，琼脂糖凝胶电泳显示，粉防己碱增加三尖杉酯碱引起的ＨＬ６０耐药细胞ＤＮＡ降解，使细胞以编程方式死亡。结果表明：粉防己碱能逆转人早幼粒白血病ＨＬ６０耐药细胞对三尖杉酯碱的耐药性，值得临床上进一步研究。
Tetracycline (0.5mg · L-1) had no significant cytotoxic effect on the proliferation of human promyelocytic leukemia HL60 cells, and decreased the colony formation rate. However, the sensitivity of HL60 No enhancement of cells. DPH fluorescent labeling method showed that tetrandrine had no effect on cell membrane fluidity; extracted DNA after drug action, agarose gel electrophoresis showed that tetrandrine increased DNA degradation of HL60 resistant cells caused by harringtonine , Programmed cell death. The results showed that tetrandrine could reverse the drug resistance of homoharringtonine in human promyelocytic leukemia HL60 cells, which deserved to be further studied in clinic.