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目的探讨辛伐他汀对高脂血症患者血脂、血小板活化功能及血液流变学的影响。方法选择100例高脂血症患者,每晚顿服辛伐他汀片20mg(舒降之)。测定治疗前和治疗4周及8周后患者血脂、血小板活化指标CD62p和CD63及血液流变学的各项指标。结果治疗4周、8周后患者TC、TG和LDL-C水平较治疗前明显下降,CD62p和CD63水平较治疗前明显下降,血液流变学指标有不同程度的改善。结论辛伐他汀对高脂血症患者,在降低血脂水平的同时可抑制血小板活化功能,改善血液流变学指标,且不良反应少。
Objective To investigate the effects of simvastatin on serum lipids, platelet activation and hemorheology in patients with hyperlipidemia. Methods 100 cases of hyperlipidemia patients, every night served simvastatin tablets 20mg (Shuzhengzhi). The levels of serum lipids, CD62p, CD63, and hemorheology in patients before and after 4 weeks and 8 weeks of treatment were measured. Results The levels of TC, TG and LDL-C in patients after 4 weeks and 8 weeks of treatment were significantly lower than those before treatment. The levels of CD62p and CD63 were significantly lower than those before treatment, and the indexes of hemorheology were improved to some extent. Conclusions Simvastatin can reduce platelet activation, improve the indexes of hemorheology and reduce the adverse reactions in hyperlipidemia patients.