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目的：为临床应用膜诱导组织再生技术扩大牙种植适应证提供理论依据。方法：在拔除狗前磨牙的同时，造成颊侧骨板缺损，即刻种植羟基磷灰石涂层钛种植体或纯钛种植体，并运用胶原膜覆盖颊侧种植体暴露面和骨面，观察种植体周骨组织再生情况。结果：经过一年的放射学和组织学观察，表明种植体周骨组织有不同程度的再生，大多数种植体稳固。结论：膜诱导组织再生技术可作用于牙种植的临床治疗。“,”The purpose of this study is providing theoretic evidence for applying guied tissue regeneration to dental unplant so as to expand the indication. Methods: Mandibular premolar 1, 2 and 3 of six adult dogs were extracte bilaterally, and buccal bone plate defects were created and measured. Eighteen screw- shaped pure titanum implants and cylindric hydroxyapatite - coated titanum implants were placed into the fresh extraction sockets. Eighteen implants were as controls, implants on the experimantal laterals were caued with collagen membranes. After 3 months, 6 months, and 12 months, the dogs were sacrificed and all specimens retrived for radiographic and histologic evaluation.Result: this study indicated that collagen membrane improve bone regeneration around dental implant. Conclnsion: Membrane guided tissue regeneration could be used in clinical treatment of dental implant.