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目的研究既往有腮腺炎病史的不孕患者与体外受精-胚胎移植(In vitro fertilization-embryo transfer,IVF-ET)中卵巢低反应的相关性。方法回顾性研究1510例不孕患者行IVF的临床资料,按照是否有腮腺炎感染史将患者分为两组,分析其与卵巢反应、妊娠结局等的关系。结果 1510例IVF-ET周期中,卵巢反应低下共755例。其中,有腮腺炎史的共219例,占总病例的14.5%,占卵巢低反应的56.2%,P=0.048;有腮腺炎病史的不孕病人,取卵周期的临床妊娠率为22%(45/205),对照组为29.7%(366/1234),有显著的统计学差异(P=0.024)。有腮腺炎史的不孕患者,IVF周期的子宫内膜厚度、正常发育胚胎数、优质胚胎数均显著低于无腮腺炎史的不孕患者,P<0.05。结论腮腺炎感染史与IVF不孕患者的卵巢低反应相关。
Objective To study the correlation between the low ovarian response in infertile patients with mumps history and in vitro fertilization-embryo transfer (IVF-ET). Methods A retrospective study of 1510 cases of infertility patients with IVF clinical data, according to whether there is a history of mumps infection will be divided into two groups, analysis of its relationship with ovarian response, pregnancy outcomes. Results 1515 cases of IVF-ET cycle, a total of 755 cases of low ovarian response. Among them, a total of 219 cases of mumps history, accounting for 14.5% of the total cases, accounting for 56.2% of ovarian low response, P = 0.048; mumps history of infertility patients, ovulation cycle clinical pregnancy rate was 22% 45/205) in the control group and 29.7% (366/1234) in the control group, with a significant statistical difference (P = 0.024). Infertility patients with a history of mumps, IVF cycle endometrial thickness, the normal number of embryos, the number of high-quality embryos were significantly lower than those without mumps history of infertility, P <0.05. Conclusion The history of mumps infection is related to the ovarian low response in IVF infertility patients.