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目的:评估阿托伐他汀与瑞舒伐他汀长期应用对冠心病患者血脂水平和肝功能的影响。方法:采用回顾性分析方法,选择我院住院冠心病患者200例,根据他汀类药物应用情况,分为阿托伐他汀组(102例)和瑞舒伐他汀组(98例),比较两组患者应用他汀后1周、1个月、3个月、6个月和12个月的血脂和肝功能水平变化。结果:两组患者治疗后各时期的TC、LDL-C水平差异均无统计学意义(P>0.05)。两组患者治疗后AST和ALT较治疗前显著升高(P<0.05),但两组间差异均无统计学意义(P>0.05)。结论:两种他汀降脂效果相似,但均可导致肝酶升高。
Objective: To evaluate the effects of long-term use of atorvastatin and rosuvastatin on blood lipid levels and liver function in patients with coronary heart disease. Methods: We retrospectively analyzed 200 hospitalized coronary heart disease patients in our hospital and divided them into atorvastatin group (n = 102) and rosuvastatin group (n = 98) according to the statin application.Compared the two groups The levels of lipids and liver function in patients at 1 week, 1 month, 3 months, 6 months and 12 months after application of statins. Results: There were no significant differences in TC and LDL-C levels between the two groups after treatment (P> 0.05). After treatment, AST and ALT in both groups were significantly higher than those before treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05). Conclusion: The two statins have similar lipid-lowering effects, but both can lead to elevated liver enzymes.