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目的探讨MMP-9、MMP-2及TIMP-1、TIMP-2在ICP患者胎盘中的表达及意义。方法选正常妊娠和ICP病例各15例,剖宫产取胎盘,免疫组化法测定MMP-9、MMP-2、TIMP-1、TIMP-2蛋白表达水平。结果胎盘MMP-9、MMP-2的阳性表达ICP组高于正常组,有显著性差异(P<0.05),胎盘TIMP-1、TIMP-2的阳性表达ICP组低于正常组,有显著性差异(P<0.05)。结论胎盘MMP-9、MMP-2、TIMP-1、TIMP-2表达差异与比例失衡,是造成ICP患者不良妊娠的原因之一。
Objective To investigate the expression and significance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in the placenta of ICP patients. Methods Fifteen cases of normal pregnancy and ICP were selected. The placenta was removed by cesarean section and the protein expressions of MMP-9, MMP-2, TIMP-1 and TIMP-2 were detected by immunohistochemistry. Results The positive expression of MMP-9 and MMP-2 in the placenta was significantly higher in the ICP group than in the normal group (P <0.05). The expression of TIMP-1 and TIMP-2 in the ICP group was lower than that in the normal group Difference (P <0.05). Conclusion The differences and imbalances of MMP-9, MMP-2, TIMP-1 and TIMP-2 in placenta are one of the causes of adverse pregnancy in ICP patients.