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目的:探讨血浆hs-CRP、IL-18及和肽素(copeptin)与冠心病类型的关系及临床意义。方法:36例对照组,41例稳定型心绞痛(SA)组,43例不稳定性心绞痛(UA)组,48例急性心肌梗死(AMI)组,均符合缺血性心肌病的诊断标准。采用免疫比浊法测定hs-CRP水平;采用放射免疫法测定血浆和肽素;采用双抗体夹心ELISA法测定血浆IL-18水平。结果:UA组与AMI组WBC、NEU、hs-CRP、IL-18、和肽素水平显著高于正常对照组(P<0.05);与UA组比较,AMI组的hs-CRP、IL-18水平显著升高;IL-18与TG、LDL-c、hs-CRP及和肽素呈正相关(P<0.05),与HDL-c呈负相关(P<0.05)。结论:血浆和肽素与IL-18水平随着冠心病严重程度的增加而升高,其水平变化对冠心病的诊断、病情的严重程度、临床危险分层具有一定的临床意义。
Objective: To investigate the relationship between plasma hs-CRP, IL-18 and copeptin and coronary heart disease and its clinical significance. Methods: Thirty-six patients in control group, 41 patients with stable angina (SA), 43 patients with unstable angina (UA) and 48 patients with acute myocardial infarction (AMI) were all diagnosed according to the criteria of ischemic cardiomyopathy. Plasma hs-CRP level was measured by immunoturbidimetry; Plasma copeptin was determined by radioimmunoassay; Plasma IL-18 level was measured by double antibody sandwich ELISA. Results: Compared with UA group, the levels of hs-CRP, IL-18 (P <0.05), but negatively correlated with HDL-c (P <0.05) .Conclusion: IL-18 levels are positively correlated with TG, LDL-c, hs-CRP and copeptin. CONCLUSIONS: The levels of plasma copeptin and IL-18 increase with the severity of coronary heart disease. The changes of plasma copeptin and IL-18 levels have clinical significance for the diagnosis of coronary heart disease, the severity of the disease and the clinical risk stratification.