To correctly capture spatial targets from cluttered and motive celestial background, a new Multi-Target Capture algorithm was proposed, which is a comparative difference algorithm based on the combination of centroid extraction and despun registration of efficient points. Moreover, this algorithm was applied in an image processing system based on the DSP featuring high speed and high performance. The procedures of image processing are as follows: first, label efficient points in the frame and extract their centroids; second, make appropriate despun registration, according to the reference rotation angles provided by Space Robot position system; third, translate and register centroid coordinates of efficient points in reference frames and get the registration points according to the principle that there are the most same centroid coordinates of efficient points when completely registered; finally, eliminate the same background points by using comparative difference method. The result shows that this image processing system can meet the needs of the whole system.