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目的探索血浆热休克蛋白70(heat shock protein 70,HSP70)作为军事应激负荷生物标志物的可行性。方法采用ELISA方法检测海军某部执行长远航任务6个月后官兵血浆中的HSP70水平的变化,采用应激评定问卷和自测健康评定量表调研其应激负荷及健康状态。结果与未执行任务组相比,执行长远航任务官兵血浆HSP70水平升高31.40%,思维和焦虑水平、负性情绪、躯体症状指标均显著高于正常水平,生理健康、心理健康和社会健康状况低于正常水平,血浆HSP70水平的升高与应激水平的升高密切相关。结论血浆HSP70水平可作为军事应激负荷评价的重要指标,为军事应激损伤预警提供科学支撑。
Objective To explore the feasibility of using heat shock protein 70 (HSP70) as a biomarker for military stress. Methods The plasma levels of HSP70 in officers and men were measured by ELISA after 6 months as a chief naval task officer. The stress load and health status were investigated by using stress assessment questionnaire and self-rated health assessment scale. Results Compared with the unmanaged task group, the plasma HSP70 level of officers and men in long-distance mission increased by 31.40%, and the levels of thinking and anxiety, negative emotions and somatic symptoms were significantly higher than the normal level, physical health, mental health and social health status Below normal level, the increase of plasma HSP70 level is closely related to the increase of stress level. Conclusion Plasma HSP70 levels can be used as an important indicator of military stress assessment to provide scientific support for early warning of military stress injury.