论文部分内容阅读
目的 :分析颅内恶性肿瘤术后局部化疗加放疗与常规化疗加放疗的疗效。方法 :随机分两组 ,局部化疗组 2 2例。两组放疗DT60～ 70Gy。局部化疗组术中放置化疗泵 ,术后将卡氮芥 (BCNU) 12 5mg注入化疗泵 ;常规组将BCNU 12 5mg与生理盐水混合后静脉输入。两组病人均为术后 6～ 12天开始化疗 ,连用 2天 ,9～ 13天后行放疗 ,放疗结束后再化疗 1～ 3次。结果 :局部化疗组平均生存期为 2 9 5个月 ,常规组 2 1 3个月 ,其中胶质母细胞效果最好 ,局部化疗副作用轻微。结论 :局部化疗加放疗比常规加放疗治疗颅内恶性肿瘤效果更满意 ,并且局部化疗更直接 ,副作用更小
Objective: To analyze the effect of local chemotherapy plus radiotherapy and conventional chemotherapy plus radiotherapy after intracranial malignant tumor. Methods: Randomly divided into two groups, local chemotherapy group 22 cases. Radiotherapy DT60 ~ 70Gy two groups. Chemotherapy pump was placed intraoperatively in the local chemotherapy group, and 125 mg of BCNU was injected into the chemotherapy pump after operation. In the conventional group, BCNU 125 mg was mixed with saline and then infused intravenously. Two groups of patients were 6 to 12 days after the start of chemotherapy, once every 2 days, 9 to 13 days after radiotherapy, radiotherapy after the end of chemotherapy 1 to 3 times. Results: The average survival time of local chemotherapy group was 295 months, while that of conventional group was 21.3 months, of which glioblastoma cells had the best effect and mild side effects of local chemotherapy. Conclusion: Local chemotherapy plus radiotherapy is more satisfied than conventional plus radiotherapy in the treatment of intracranial malignant tumors, and local chemotherapy is more direct and less side effects