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应用细胞原位杂交技术，观察经重组小鼠白细胞介素-19（IL-1β）处理后的体外培养的新生1d大鼠中脑黑质神经元c－jun基因的表达．结果显示，培养的黑质细胞多为酪氨酸羟化酶阳性神经元，IL-1β可诱导体外培养的黑质神经元c－junmRNA表达，高水平的表达出现在IL-1β处理后2～4h。说明IL－1β有兴奋黑质神经元的作用，并提示黑质神经元上可能存在IL－1β受体．
The in situ hybridization technique was used to observe the expression of c-jun gene in substantia nigra neurons of neonatal 1d rats treated with recombinant mouse interleukin-19 (IL-1β). The results showed that tyrosine hydroxylase positive neurons were mostly cultured in substantia nigra, IL-1β could induce the expression of c-jun mRNA in substantia nigra neurons cultured in vitro, 4h. IL-1βexpressed the neurons of the substantia nigra and suggested that there may be IL-1βreceptor on the substantia nigra neurons.