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Prophylactic activity of flunarizine in migraine is attributed to its antioxid ant properties and to the relief of cerebral vasospasm in which nitric oxide (NO ) is involved. We investigated the antimigraine activity of flunarizine and its influence on NO and oxidative marker bioavailability in 25 subjects suffering fr om migraine without aura and in 25 healthy controls. Urinary samples collected b efore and after treatment with flunarizine (5 mg orally per day for 6 months) we re assayed for NO stable metabolites (NOx) and thiobarbituric acid reactive subs tances (TBARS). Urinary levels of NO x and TBARS were higher in migraine suffere rs before treatment than in healthy controls. No differences were observed in NO x levels in migraine sufferers, before and after flunarizine treatment; urinary TBARS levels were decreased after flunarizine treatment (P < 0.05) and remained persistently higher than in healthy controls (P < 0.05). Our results suggest th at flunarizine did not prevent NOmediated vasodilatation, while it proved effect ive in limiting the oxidative reactions occurring in migraine sufferers.
Prophylactic activity of flunarizine in migraine is attributed to its antioxid ant properties and to the relief of cerebral vasospasm in which nitric oxide (NO) is involved. We investigated the antimigraine activity of flunarizine and its influence on NO and oxidative marker bioavailability in 25 fr om migraine without aura and in 25 healthy controls. Urinary samples collected bfore and after treatment with flunarizine (5 mg orally per day for 6 months) we re assayed for NO stable metabolites (NOx) and thiobarbituric acid reactive subs tances (TBARS) . Urinary levels of NO x and TBARS were higher in migraine suffere rs before treatment than in healthy controls. No differences were observed in NO x levels in migraine sufferers, before and after flunarizine treatment; urinary TBARS levels were decreased after flunarizine treatment (P < 0.05) and remained persistently higher than in healthy controls (P <0.05). Our results suggest th at flunarizine did not prevent NOm ediated vasodilatation, while it proved effective ive in limiting the oxidative reactions occurring in migraine sufferers.