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信号转导子和转录激活子 (signaltransducerandactivatoroftranscription ,STAT)家族成员参与了许多细胞因子的信号转导 ,从而对免疫反应、炎症反应和细胞的生长、分化等进行调节。本文简要介绍STAT家族的功能结构域、STAT蛋白在介导细胞因子信号时的抑制性调节及在细胞因子信号转导中的作用。
Signal transducers and activators of signal transduction (STAT) family members are involved in the signal transduction of many cytokines to regulate immune responses, inflammatory responses and cell growth and differentiation. This article briefly describes the functional domains of the STAT family, the inhibitory regulation of STAT proteins in mediating cytokine signaling, and their role in cytokine signaling.