丙戊酸(Valproic Acid VPA)为一种新型的广谱抗癫痫药,其抗癲痫的独特疗效已得到公认。此外,近年来用本药治疗顽固性呃逆、僵人征群、小舞蹈病等亦取得较满意的效果。但在日益广泛的临床应用中,也相继发现病人出现新的不良反应,甚至可能因肝功能衰竭而致死。本文就其近年来所发现的主要不良反应,及其发生机制和防治原则综述如下。 VPA最常见的不良反应有恶心、食欲减退等胃肠道症状,嗜睡、头晕、轻度震颤等精神、神经症状,偶而可见脱发、 Valproic Acid VPA is a new broad-spectrum antiepileptic drug whose unique anti-epileptic effect has been recognized. In addition, in recent years, the use of the drug treatment of intractable hiccups, stiff people syndrome, small chorea disease also achieved more satisfactory results. However, in an increasingly wide range of clinical applications, patients have also found new adverse reactions, and may even be fatal due to liver failure. In this paper, the main adverse reactions found in recent years, and its mechanism of occurrence and prevention principles summarized below. VPA most common adverse reactions are nausea, loss of appetite and other gastrointestinal symptoms, drowsiness, dizziness, mild tremor and other mental symptoms of neurotransmission, and occasionally visible hair loss,