多发性硬化(multiple sclerosis,MS)是原发性中枢神经系统的炎症性脱髓鞘疾病。国外资料表明45%～65%的 MS 患者可合并认知功能损害,其中约10%的患者症状可以非常严重。相关分析还表明,MS 患者发生认知损害的概率和严重程度与病程年限、复发次数、躯体残疾状况无明显相关,即使病 Multiple sclerosis (MS) is an inflammatory demyelinating disease of the primary central nervous system. Foreign data show that 45% to 65% of MS patients may be associated with cognitive impairment, of which about 10% of patients with symptoms can be very serious. Correlation analysis also showed that the probability and severity of cognitive impairment occurred in patients with MS and disease duration, frequency of recurrence, physical disability status no significant correlation, even if the disease