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目的探讨生肌白玉膏对大鼠深Ⅱ度烧伤创面β1整合素及角蛋白19阳性细胞数量和分布的影响及其与创面愈合之间的关系。方法制备深Ⅱ度烫伤大鼠模型。分别在药物治疗组、阳性对照组、模型组创面涂抹生肌白玉膏、美宝湿润烧伤膏、生理盐水,正常对照组不涂任何药物,第3,7,14,21天比较三组创面愈合率及β1整合素及角蛋白19阳性细胞数量和分布。结果第3天三组β1整合素及K19阳性细胞数比较差异无统计学意义(P>0.05);第7,14,21天药物治疗组与模型组比较差异有统计学意义(P<0.05),阳性对照组与模型组差异有统计学意义(P<0.05),药物治疗组与阳性对照组比较差异无统计学意义(P>0.05)。创面内表皮干细胞的数量与创面愈合率的关系呈正相关。结论生肌白玉膏调节皮肤创面组织中β1整合素及角蛋白19的表达,对烧伤创面的修复有促进作用。
Objective To investigate the effect of Shengji Baiyu Ointment on the number and distribution of β1 integrin and keratin 19 positive cells in deep second degree burn wounds in rats and its relationship with wound healing. Methods Deep Ⅱ degree scald rat model was prepared. The patients in the drug treatment group, the positive control group and the model group were treated with Baiyao Baiyao cream, MEBO MEBO, normal saline and normal control group without any drug. The wound healing was compared on the 3rd, 7th, 14th and 21st day Rate and β1 integrin and keratin 19-positive cells in the number and distribution. Results There was no significant difference in the number of β1 integrin and K19 positive cells among the three groups on the third day (P> 0.05). On the 7th, 14th and 21st days, there was significant difference between the drug treatment group and the model group (P <0.05) (P <0.05). There was no significant difference between the positive drug group and the positive control group (P> 0.05). There was a positive correlation between the number of epidermal stem cells in wounds and wound healing rate. Conclusion Shengji Baiyu cream regulates the expression of β1 integrin and keratin 19 in the skin wound tissue, which may promote the repair of burn wounds.