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目的探讨中青年脑梗死患者急性期血清尿酸水平与脑梗死发病和预后的关系。方法我科首次发病的中青年急性脑梗死病人65例;选择我院体检中心的健康查体者55例为对照组。用酶法经日立7600全自动生化分析仪测定脑梗死患者于入院第1天的血清尿酸水平,同时测定对照组的血清尿酸水平。采用美国国立卫生研究院卒中量表(NIHSS)标准分别在入院时和入院后4周对脑梗死组进行临床神经功能缺损评分(NDS)。结果①急性脑梗死患者血清尿酸水平明显高于健康对照组,二者比较有显著性差异(t=14.004,P<0.05)。②脑梗死患者随病情严重程度增加血清尿酸水平升高,且差异具有显著性(F=92.639,P<0.05)。③脑梗死患者血清尿酸水平越高,患者预后也越差(2χ=20.746,P<0.001)。结论血清尿酸水平与中青年急性脑梗死密切相关,血清尿酸水平可作为常规检测指标来预测梗死的发生和患者预后。
Objective To investigate the relationship between serum uric acid level and the incidence and prognosis of cerebral infarction in young and middle-aged patients with acute cerebral infarction. Methods The first incidence of acute cerebral infarction in our department in 65 cases of patients; select our hospital physical examination 55 cases of healthy people as the control group. Serum uric acid levels of patients with cerebral infarction on the first day of hospital admission were determined by enzymatic method and Hitachi 7600 automatic biochemical analyzer. Serum uric acid levels in the control group were also measured. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the clinical neurological deficit score (NDS) at admission and 4 weeks after admission. Results ① Serum uric acid levels in patients with acute cerebral infarction were significantly higher than those in healthy controls (t = 14.004, P <0.05). ② Serum uric acid levels increased with the severity of illness in patients with cerebral infarction, and the difference was significant (F = 92.639, P <0.05). ③ The higher serum uric acid level in patients with cerebral infarction, the worse the prognosis of patients (2χ = 20.746, P <0.001). Conclusions Serum uric acid level is closely related to middle-aged and young patients with acute cerebral infarction. Serum uric acid level can be used as a routine measure to predict the occurrence of infarction and the prognosis of patients.