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目的探讨氨甲喋呤不同给药途径治疗输卵管妊娠的疗效。方法选取我院2012年11月至2013年11月所收治的104例未破裂型输卵管妊娠患者,将其随机分为3组,分别为治疗Ⅰ组(肌内注射甲氨喋呤+米非司酮)、治疗Ⅱ组(采用宫腔镜+米非司酮)、治疗组Ⅲ组(给予氯甲喋呤)。结果治疗Ⅰ组治愈30例(93.8%),治疗后包块直径为(2.7±3.1)cm,治疗1周后β-HCG下降率为80.20%;治疗Ⅱ组治愈26例(74.3%),治疗后包块直径为(3.5±2.8)cm,治疗1周后β-HCG下降率为54.4%;两组患者比较差异有统计学意义(P<0.05),治疗Ⅲ组治愈20例(54.0%),治疗后包块直径为(3.7±38)cm,治疗1周后β-h CG下降率为42.6%;与治疗I组相比,两组患者比较差异有统计学意义(P<0.05)。结论大剂量给予甲氨蝶呤配合服用米非司酮治疗输卵管妊娠,具有高效、经济、安全等优点。
Objective To investigate the efficacy of different routes of administration of methotrexate in the treatment of tubal pregnancy. Methods A total of 104 patients with unruptured tubal pregnancy who were treated in our hospital from November 2012 to November 2013 were randomly divided into three groups: treatment group Ⅰ (methotrexate + mifepristone Ketone), treatment group Ⅱ (hysteroscopy + mifepristone), treatment group Ⅲ (given methotrexate). Results After treatment, 30 cases (93.8%) were cured in group Ⅰ, and the diameter of mass was (2.7 ± 3.1) cm after treatment. The decrease rate of β-HCG was 80.20% after treatment for one week and 26 cases (74.3% The diameter of posterior mass was (3.5 ± 2.8) cm and the rate of decline of β-HCG was 54.4% after 1 week of treatment. The difference between the two groups was statistically significant (P <0.05) (3.7 ± 38) cm after treatment. The decrease rate of β-h CG was 42.6% after 1 week of treatment. Compared with treatment group I, the difference between the two groups was statistically significant (P <0.05). Conclusion High dose methotrexate combined with mifepristone for tubal pregnancy has the advantages of high efficiency, economy and safety.