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目的:探讨反流性食管炎(RE)的病理生理学基础。方法:应用比色法和放免法分别测定20例RE和20例无食管炎(NE)者下食管括约肌(LES)局部组织内一氧化氮(NO)、血管活性肠肽(VIP)和P物质(SP)的含量。结果:不同程度RE组LES组织中的NO和VIP含量均明显高于NE组(P<0.01),SP含量则明显低于NE组(P<0.01);不同程度RE组各组间LES组织中的NO、VIP和SP含量差异均有非常显著性意义(P<0.01)。RE的严重程度与NO、VIP含量呈显著正相关(r_(NO)=0.983,P<0.01;r_(VIP)=0.964,P<0.01),与SP呈显著负相关(r_(SP)=-0.966,P<0.01)。NO和VIP含量之间呈显著正相关(r=0.972,P<0.01)。NO与SP含量之间及VIP与SP含量之间均呈显著负相关(r_(NO)=-0.967,P<0.01;r_(VIP、SP)=-0.916,P<0.01)。结论:NO、VIP和SP在RE的发病机制中发挥着重要的病理生理学作用。
Objective: To investigate the pathophysiology of reflux esophagitis (RE). Methods: The levels of nitric oxide (NO), vasoactive intestinal peptide (VIP) and substance P in 20 esophageal sphincter (LES) tissues of 20 patients with RE and 20 patients without esophagitis were determined by colorimetry and radioimmunoassay. (SP) content. Results: The contents of NO and VIP in LES tissue of RE group were significantly higher than those in NE group (P <0.01), but the content of SP in RE group was significantly lower than that in NE group (P <0.01) The differences of NO, VIP and SP contents were significant (P <0.01). There was a significant positive correlation between the severity of RE and NO and VIP (r NO = 0.983, P <0.01; r VIP = 0.964, P <0.01) 0.966, P <0.01). There was a significant positive correlation between NO and VIP (r = 0.972, P <0.01). There was a significant negative correlation between NO and SP content and between VIP and SP content (r_ (NO) = -0.967, P <0.01; r_ (VIP, SP) = -0.916, P <0.01). Conclusion: NO, VIP and SP play an important pathophysiological role in the pathogenesis of RE.