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肺淋巴液的蛋白质含量与肺组织间液极为接近,肺淋巴流量及蛋白质含量的变化,可动态反映肺内液体及蛋白质跨肺血管壁移动的情况,以及肺微血管壁通透性的改变;测定肺淋巴液中物质成份的浓度及酶的活性,可以了解肺的代谢机能,探讨肺损伤的机制。Warren和Drinker 1942年首先在狗经右淋巴导管收集肺淋巴液。七十年代,Staub等人创建并完善了绵羊慢性肺淋巴痿模型,可以在清醒和无应激的动物收集肺淋巴液。此法已用于探讨在生理和病理状态下,肺内液体和蛋白质交换的规律,以及实验性肺水肿和肺损伤的研究中,现综述如下。
Pulmonary lymphatic fluid protein content and pulmonary interstitial fluid is very close to the changes in lung lymph flow and protein content can be dynamically reflected in the pulmonary fluid and protein across the pulmonary vascular wall movement and pulmonary microvascular wall permeability changes; determination Lung lymph fluid concentration of substance and enzyme activity, can understand the lung’s metabolic function, explore the mechanism of lung injury. Warren and Drinker first collected pulmonary lymphatic fluid through the right lymphatic duct in 1942. In the 1970s, Staub et al. Created and refined a model of chronic pulmonary xanthoma in sheep that can collect pulmonary lymphatic fluid in awake and stress-free animals. This method has been used to investigate the physiological and pathological conditions, the lung fluid and protein exchange law, and experimental pulmonary edema and lung injury research, are summarized below.