论文部分内容阅读
测定肾病综合征（ＮＳ）患儿２０种血清蛋白成分的含量及其它３项指标，并测定尿液 中总蛋白（ＴＰ）及１１种不同分子量蛋白质的含量变化。与正常儿童比较，ＮＳ 患儿血清Ｃ５、Ｃ１－ＩＮＨ、 ＩｇＭ、ＨＰ、α２Ｍ含量均极显著升高，Ｐｇ含量显著升高，Ｃ１ｑ、ＩｇＧ、ＡＬｂ、Ｔｆ含量极显著降低，ＣＩＣ 浓度 极显著升高而ＣＨ５０活性显著降低，ＥＳＲ极显著升高。表明ＮＳ时有抗原刺激机体介导体液免疫应 答，并存在抗体生成异常。机体在对抗病理损伤时，表现出称为急性期蛋白的血浆蛋白成分的浓度 改变，参与急性期应激反应。ＮＳ患儿急性期尿液的ＴＰ及１１种蛋白成分含量均极显著高于正常儿 童，且随病情缓解，各项指标逐渐恢复正常，表明ＮＳ时肾小球滤过膜具有滤过物分子大小选择和 电荷选择双重控制，这种选择对各种血浆蛋白成分的漏出量起决定作用。
To determine the contents of 20 kinds of serum protein in children with nephrotic syndrome (NS) and other 3 indexes, and to determine the content of total protein (TP) and 11 kinds of different molecular weight proteins in urine. Compared with normal children, the contents of C5, C1-INH, IgM, HP and α2M in NS children were significantly increased, Pg content was significantly increased, C1q, IgG, ALb, Tf content was significantly reduced, CIC concentration was significantly increased High and CH50 activity was significantly reduced, ESR was significantly increased. That when NS antigen-stimulated body humoral immune response mediated, and the presence of antibody abnormalities. In the fight against pathological damage, the body shows a change in the concentration of a plasma protein component called the acute phase protein involved in the acute phase of the stress response. The contents of TP and 11 protein in urine of children with acute NS were significantly higher than those of normal children, and gradually recovered to normal with the remission, which indicated that glomerular filtration membrane Choice and double the choice of charge control, the choice of a variety of plasma protein components play a decisive role in the leakage.