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目的系统评价表皮细胞因子(epidermal growth factor,EGF)基因61A/G多态性与食管癌风险的相关性。方法计算机检索PubMed、EMbase、CJFD、CBM、CNKI、VIP及WanFang Data,检索时限从建库至2013年1月1日,收集关于EGF基因61A/G多态性与食管癌发病风险的病例-对照研究。由2位评价者按照纳入和排除标准独立选择文献、提取资料和评价质量后,采用RevMan 5.1和Stata 12.0软件进行Meta分析。结果共纳入6个病例-对照研究,1 448例食管癌患者和1 728例健康对照人群。Meta分析结果显示,EGF基因61A/G多态性与食管癌风险的相关性无统计学意义:显性遗传模型[AG+GG vs.AA:OR=1.22,95%C(I0.91,1.65)];隐性遗传模型[GG vs.AG+AA:OR=1.35,95%CI(0.94,1.94);AG vs.AA:OR=1.12,95%CI(0.93,1.35);GG vs.AA:OR=1.43,95%CI(0.83,2.47)]。基于人种的亚组分析显示,EGF基因61A/G多态性可增加白种人罹患食管癌的风险:显性遗传模型[AG+GG vs.AA:OR=1.39,95%CI(1.14,1.71)];隐性遗传模型[GG vs.AG+AA:OR=1.75,95%CI(1.37,2.25);GG vs.AA:OR=1.93,95%CI(1.47,2.55)]。但与亚洲人群食管癌风险无明显相关。结论基于目前研究结果,可以认为EGF基因61A/G多态性与食管癌易感性无明显相关性,而EGF基因61A/G多态性可能增加白种人罹患食管癌风险。受纳入研究的数量和质量限制,以上结论需要大样本研究进行验证。
Objective To evaluate the relationship between the 61A / G polymorphism of epidermal growth factor (EGF) gene and the risk of esophageal cancer. Methods PubMed, EMbase, CJFD, CBM, CNKI, VIP and WanFang Data were searched by computer. The retrieval time was from the establishment of the database to January 1, 2013. The data of 61 A / G polymorphisms of EGF gene and the risk of esophageal cancer were collected. the study. Two reviewers independently selected the literature according to the inclusion and exclusion criteria, extracted data and evaluated the quality. Meta-analysis was performed using RevMan 5.1 and Stata 12.0 software. Results A total of 6 case-control studies were included, with 1 448 esophageal cancer patients and 1 728 healthy controls. Meta analysis showed that there was no significant correlation between the 61A / G polymorphism of EGF gene and the risk of esophageal cancer. The dominant genetic model [AG + GG vs. AA: OR = 1.22, 95% C (I0.91, 1.65 ); Recessive genetic model [GG vs. AG + AA: OR = 1.35,95% CI (0.94,1.94); AG vs.AA: OR = 1.12,95% CI : OR = 1.43, 95% CI (0.83, 2.47)]. Based on ethnic subgroup analysis, 61A / G polymorphism of EGF gene increased the risk of esophageal cancer in Caucasians: dominant genetic model [AG + GG vs. AA: OR = 1.39, 95% CI (1.14, 1.71)]; recessive genetic model [GG vs. AG + AA: OR = 1.75, 95% CI (1.37, 2.25); GG vs. AA: OR = 1.93, 95% CI (1.47, 2.55)]. But no significant correlation with the risk of esophageal cancer in Asian populations. Conclusions Based on the current findings, it is believed that the 61A / G polymorphism of EGF gene has no significant association with susceptibility to esophageal cancer, whereas the 61A / G polymorphism of EGF gene may increase the risk of esophageal cancer in Caucasians. Due to the quantity and quality limitations of the studies included, the above conclusions require large sample studies to be validated.