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测定６０例健康成人和８０例胸腔恶性肿瘤患者血清过氧化脂质和唾液酸含量。肿瘤患者血清游离过氧化脂质和蛋白结合唾液酸含量分别为２．３６±０．５５μｍｏｌ·Ｌ－１和０．７４±０．２４ｍｍｏｌ·Ｌ－１，明显高于对照组水平（１．６１±０．２０μｍｏｌ·Ｌ－１、０．４８±０．１４ｍｍｏｌ·Ｌ－１）。游离过氧化脂质的特异性为９８％，蛋白结合唾液酸的特异性９６．７％，敏感性分别为７６．３％和５７．５％。两者联合测定敏感性高达８７．５％，是较好的肿瘤标志物。手术后２周内患者血清游离过氧化脂质和蛋白结合唾液酸含量仍处于高水平。
The levels of serum lipid peroxides and sialic acid in 60 healthy adults and 80 patients with malignant tumors of the chest were measured. Serum free lipid peroxides and protein-bound sialic acid levels in tumor patients were 2.36±0.55 μmol·L-1 and 0.74±0.24 mmol·L-1, respectively, which were significantly higher than those in the control group (1.61). ±0.20 μmol·L-1, 0.48±0.14 mmol·L-1). The specificity of free lipid peroxides was 98%, the specificity of protein-bound sialic acid was 96.7%, and the sensitivities were 76.3% and 57.5%, respectively. The combined sensitivity of the two assays is as high as 87.5%, which is a good tumor marker. Serum free lipid peroxide and protein-bound sialic acid levels were still at high levels within 2 weeks after surgery.