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目的:综述近年来2型糖尿病病证结合动物模型的几种建立方法。方法:主要对2型糖尿病病证结合动物模型的方法进行综述和评价。结果:2型糖尿病病证结合动物模型主要可分为肾阴虚证2型糖尿病动物模型、脾阴虚证2型糖尿病动物模型、肾阳虚证2型糖尿病动物模型、脾气虚证2型糖尿病动物模型、血瘀证2型糖尿病动物模型、气阴两虚证2型糖尿病动物模型、阴阳两虚证2型糖尿病动物模型7种。结论:上述7种动物模型先使用高脂饲养联合STZ的方法来建立2型糖尿病动物模型,在此基础上使用化学药物、中药制剂和物理刺激等方法建造病证结合动物模型,并从临床表现、特异性指标和方剂反证三个方面进行综合评价,判断建造病症结合动物模型具有可行性。
OBJECTIVE: To summarize several methods for establishing a combined animal model of type 2 diabetes in recent years. Methods: The methods of combining type 2 diabetes with animal model were reviewed and evaluated. Results: The animal model of type 2 diabetes syndromes can be divided into two groups: type 2 diabetes mellitus with kidney yin deficiency syndrome, type 2 diabetes mellitus with spleen yin deficiency syndrome, type 2 diabetes mellitus with kidney yang deficiency syndrome, type 2 diabetes mellitus with deficiency of spleen deficiency syndrome Animal model, animal model of type 2 diabetes mellitus with blood stasis, type 2 diabetes mellitus with deficiency of qi and yin, and type 2 diabetes mellitus with yin and yang deficiency syndrome. Conclusion: The animal models of type 2 diabetes mellitus were established by using high-fat diet combined with STZ. The animal model was established by using chemical drugs, traditional Chinese medicine preparations and physical stimuli, and the animal model was established from clinical manifestations , Specificity and prescription anti-card three aspects of a comprehensive evaluation to determine the construction of the disease animal model is feasible.