随着超声造影剂的不断发展,超声造影剂在疾病的诊断方面发挥了巨大作用并且在疾病治疗方面也已成为国内外的研究热点。以脂质微泡为载体,将特定的药物、基因与脂质微泡相连接,与超声联用可达到药物在目标组织的富集,从而更好的发挥药物的治疗作用,并减少药物在全身的不良反应。国内外研究已有报道超声可增强溶栓药物的作用[1-3],若能将溶栓药物与微泡相结合将更有助于局部溶栓 With the continuous development of ultrasound contrast agents, ultrasound contrast agents have played a great role in the diagnosis of diseases and have become a hot research field at home and abroad in disease treatment. With lipid microbubbles as a carrier, the specific drugs, genes and lipid microbubbles connected with ultrasound can be achieved in the target drug enrichment of drugs in order to better play a therapeutic role of drugs and reduce the drug in Systemic side effects. Domestic and foreign studies have reported that ultrasound can enhance the role of thrombolytic drugs [1-3], if the combination of thrombolytic drugs and microbubbles will be more helpful to local thrombolysis