INTRODUCTIONrnOsteoclasts are myeloid lineage cells that resorb bone.1–2 As bone constantly remodels, remodeling is tightly regulated by osteo-clasts, bone-forming osteoblasts, and osteocytes.3 The balance between bone resorption and formation is critically important for the maintenance of skeletal integrity and disruption of this balance results in pathological changes in bone structure and quality. Overly active osteoclasts lead to an imbalance, tipping the scale toward more bone resorption than formation and leading to pathological bone loss, such as occurs in patients with osteo-porosis.