Isoangustone A是一种来源于甘草的异戊烯基化黄酮类化合物,具有抗菌、抗氧化、抗炎、抗肿瘤等活性。为了增加其结构多样性,本文利用丝状真菌冻土毛霉(Mucor hiemalis CGMCC 3.14114)对该化合物进行微生物转化,共分离得到3个新化合物。通过NMR和MS谱学分析,其结构分别鉴定为isoangustone A 7-O-glucoside(2),isoangustone A 7-O-glucoside-4’-O-sulfate(3),以及isoangustone A 7,3’-di-O-glucoside(4)。主要转化反应为C-7位糖基化反应。此外,硫酸酯化反应是较为罕见的微生物转化反应。 Isoangustone A is a prenyllated flavonoid derived from licorice and has antibacterial, anti-oxidant, anti-inflammatory and anti-tumor activities. In order to increase their structural diversity, three novel compounds were isolated from the filamentous fungus Mucor hiemalis CGMCC 3.14114. Their structures were identified as isoangustone A 7-O-glucoside (2), isoangustone A 7-O-glucoside-4’-O-sulfate (3) and isoangustone A 7,3’- di-O-glucoside (4). The main conversion reaction is C-7 glycosylation. In addition, the sulfation reaction is a relatively rare microbial conversion reaction.