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目的探讨染色体多态性与不良妊娠之间的关系。方法对送检外周血的23 532例患者按常规技术方法制备外周血染色体,分析染色体多态性核型。结果染色体多态性检出892例,异常检出率为3.79%。其中次缢痕区加长或缩短有555例,9号染色体倒位153例,D和G组随体变异151例,短臂的加长或缩短26例,染色体着丝粒异染色质增多7例。结论染色体多态性在临床上具有很大的争议性,部分文献主张多态性对不良妊娠没有什么影响,但部分文献提示多态性在一定内外环境影响下,可产生一定临床病理表现,所以临床应予以重视。
Objective To explore the relationship between chromosome polymorphism and adverse pregnancy. Methods Peripheral blood chromosomes were prepared from 23 532 patients who were tested for peripheral blood by routine techniques. The karyotypes of chromosomes were analyzed. Results Chromosome polymorphism was detected in 892 cases, the detection rate was 3.79%. Among them, there were 555 cases of lengthening or shortening in secondary lesion area, 153 cases of inverted position on chromosome 9, 151 cases of variant in group D and G, 26 cases of shortening or shortening of short arm, and 7 cases of abnormalities of chromosome centromeric heterochromatin. Conclusion Chromosome polymorphism is clinically controversial. Some of the literature advocates that polymorphisms have no effect on adverse pregnancy. However, some reports suggest that some polymorphisms may produce some clinical and pathological findings under the influence of internal and external environment. Therefore, Clinical should pay attention.