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目的研讨外科手术患者运用泮托拉唑与法莫替丁治疗对术后应激性溃疡的预防效果。方法随机对我院2013年5月-2016年5月接诊的72例手术患者进行分组试验与研究,Ⅰ组36例接受法莫替丁治疗,Ⅱ组36例接受泮托拉唑静脉滴注,评估该两种方案对术后应激性溃疡的预防疗效、胃液p H测定情况与安全性。结果Ⅱ组患者接受治疗后的总有效率为91.7%,相比Ⅰ组的总有效率(66.7%)显著提高,数据满足P<0.05,有统计学意义。经胃液p H值检测,显示Ⅱ组治疗后2d、4d的胃液p H值相比Ⅰ组均显著提高,数据满足P<0.05,有统计学意义。两组在试验期间均有产生副反应,Ⅱ组总发生率(2.8%)显著比Ⅰ组(16.7%)降低,数据满足P<0.05,有统计学意义。结论与法莫替丁相比,泮托拉唑对手术患者术后应激性溃疡的预防作用更理想,且药物更安全、对胃液p H值改善更明显,值得推荐。
Objective To investigate the preventive effect of pantoprazole and famotidine on postoperative stress ulcer in patients undergoing surgery. Methods A total of 72 surgical patients admitted to our hospital from May 2013 to May 2016 were randomly divided into trial group and study group Ⅰ, 36 patients received famotidine, and 36 patients in group Ⅱ received intravenous injection of pantoprazole , To evaluate the prevention and treatment effect of the two regimens on postoperative stress ulcer, determination of p H in gastric juice and safety. Results The total effective rate of patients in group Ⅱ after treatment was 91.7%, which was significantly higher than that in group Ⅰ (66.7%). The data met the significance of P <0.05. The p H value of gastric juice showed that p value of gastric juice in group Ⅱ was significantly higher than that in group Ⅰ at 2 and 4 days after treatment, and the data met the significance of P <0.05. The two groups had side effects during the trial. The total incidence of group II (2.8%) was significantly lower than that of group I (16.7%). The data met the criteria of P <0.05, which was statistically significant. Conclusions Compared with famotidine, pantoprazole is more effective in preventing postoperative stress ulcer in patients undergoing surgery and the drug is safer. It is also worth recommending that pantoprazole improves p H value in gastric juice significantly.