最近,来自美国匹斯堡大学医学院的MF Brown等人对癌细胞坏死引发机制进行了研究。首先,研究人员以人大肠癌细胞系HCT116为研究对象,人为敲除了细胞中的caspase 3蛋白。出人意料的是:敲除后的细胞系HCT116-/-对5-FU等癌症药物处 Recently, MF Brown et al from the University of Pittsburgh Medical School studied the mechanism of cancer cell necrosis. First, the researchers to human colorectal cancer cell line HCT116 as a research object, human knockout of the cell caspase 3 protein. Surprisingly, the knock-out cell line HCT116 - / - responds to cancer drugs such as 5-FU