论文部分内容阅读
目的研究宫颈上皮内瘤变(CIN)Ⅱ级患者随访与抗病毒干预效果及引发CIN的危险因素,为建立高危评价体系提供依据。方法选取2013—2014年在永康市第一人民医院妇科做阴道镜下宫颈组织活检,病理分型为CINⅡ的患者60例,进行2年的基液细胞学检查(TCT)和人乳头瘤病毒(HPV)随访研究及危险因素分析。结果至随访12个月时,有1例失访和2例施行了CINⅢ级手术治疗,其余患者TCT和HPV检查均属正常的比例为45.61%(26/57);至随访24个月时,有2例失访和5例施行了CINⅢ级手术治疗,其余患者TCT和HPV检查均属正常的比例为88.68%(47/53)。多因素非条件Logistic回归分析显示,年龄(OR=1.207,95%CI:1.062~1.231)、无性生活防护(OR=0.274,95%CI:0.103~0.811)、多伴侣性行为(OR=2.032,95%CI:1.038~3.941)和性传播疾病感染(OR=15.402,95%CI:5.873~43.904)是CIN患者致病的独立危险因素(P均<0.05)。结论大部分CIN患者可通过随访干预治疗而不施行手术治愈;早期诊断发现CIN并通过干预治疗可降低复发率。
Objective To investigate the effect of follow-up, antiviral intervention and risk factors of CIN in patients with cervical intraepithelial neoplasia (CIN) Ⅱ level, and provide basis for establishing high-risk evaluation system. Methods From 2013 to 2014, 60 patients with colposcopic biopsy of cervix under gynecological examination of gynecology in Yongkang First People ’s Hospital were enrolled. Two years of liquid - based cytology (TCT) and human papillomavirus HPV) follow-up study and analysis of risk factors. Results One year follow-up and one case of CINⅢ-level surgery were followed up for 12 months. The remaining TCT and HPV were normal in 45.61% (26/57) patients. At 24 months of follow-up, There were 2 cases lost to follow-up and 5 cases underwent CIN Ⅲ operation. The remaining patients had a normal TCT and HPV test of 88.68% (47/53). Multivariate non-conditional Logistic regression analysis showed that age (OR = 1.207, 95% CI: 1.062-1.231), asexual life protection (OR = 0.274, 95% CI: 0.103-0.811) 95% CI: 1.038 ~ 3.941) and STD infection (OR = 15.402,95% CI: 5.873 ~ 43.904) were independent risk factors for CIN patients (all P <0.05). Conclusion Most patients with CIN can be cured by follow-up intervention without surgical treatment. Early diagnosis of CIN and intervention can reduce the recurrence rate.